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KMID : 0378019580010010017
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New Medical Journal
1958 Volume.1 No. 1 p.17 ~ p.39
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Experimental studies on the Influence of the Reticulo-Endothelial System Blockade on Allergic changes in the Thymus.
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Abstract
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Series of studies regarding to the relation of the
R.E.S. to allergic changes were carried out by many
investigators. Boyd, Topley and Wilson, Wilson and
Bloom, Hayashi and Maruyama described the produc-
tion of antibody in the R.E.S.. Oka found that anaphyla
ctic shock was inhibited by splenectomy. Prof.Yun, Far-
mer reported that anaphylactic shock was inhibited by
thymusectomy: Meanwhile, Ogawa and Isida recogni-
zed that , anaphylactic shock was aggrevated by the
administration of thymic substance. Juiigeblut and
Berlot, Gay and Clark, Tuft, Oka, Sakurai, Watanave,
Hirakawa and Ozima and Iwaii also recognized
inhibition of anaphylactic shock in !he R.E.S. blockaded
animals. Akahoshi, Apitz, Klinge and Umasugi
reported that the main hyperallergic changes in liver
were changed´ in the stellet cells. Haedel and,Karsue
have reported that anaphylactic- shock was inhibited
by the-injection of a large dose of India ink solution
and was aggrevated by a small dose of India ink
solution: Prof. Yun, Moldovan, Slavoacet et Zolog
found a protective substance against anaphylactic shock
in the serum of the R. E. S. blockaded animal and
claimed that the protective substance seems to be
corresponded by the endocrine function in the R.E.S..Seul
has reported that allergic in the liver were
inhibited either by the injection of India ink solution
or serum from the R. E. S. blockaded animal. ´Song
also has recognized that the injection of India ink
solution or serum from the R. E. S. blockaded animal
inhibited allergic changes in the lungs.
The experiment to be reported in this paper was
to study the influence of the R.E.S. on allergic changes
in thymus.
Experimental material and method
Normal rabbit weighing around 800 grams were
used. I cc. of normal horse serum per kilogram of
horse serum per kilogram of body weight given´ locally .
in thymus parencyma two weeks later.: For blockading
the R.E.S., India ink solution obtained by the sterili-
zation of i0% of BOPIL MUkJIP saline. solution was
used.
1. Nonsensitizing group.
The normal horse serum was injected locally in´the
thymus parenchyma without sensitization.
2. Sensitizing group.
The normal horse serum was injected subcutaneo
4 times for sensitizing. For reinjection, O.I cc, of
normal horse serum per kilogram of body weight was
given to the thymus parenchyma two weeks later.
3. Single injection of 50c. India ink solution.
Allergic changes were observed in rabbits into
which India ink solution, 5 cc. per kilogram of body
Weight, was injected- intravenously 24 hours before
sensitization.
4. Plural injection of 5 cc. India ink solution.
Allergic changes were observed An rabbits into
which India, ink :solution, 5 cc. per kilogram of body
weight, was injected intravenouslly 6 times with 12
hours intervals 24 hours before sensitization.
5. Injection of the serum from normal rabbits.
Allergic changes in. the thymus were observed in
rabbits into which normal rabbit serum, 2 cc. per
kilogram of body weight was injected intravenously
24 hours before sensitization.
6. Injection of the serum from single injection of
5 cc. India ink solution.
Serum from rabbits, 2 cc. per kilogram of body
weight,´ into ´which 5 cc, of India ink solution per
kilogram. of body weight had,,been injected was given
24 hours before sensitization. `
7. Injection´ of the serum from "plural injection of
5 cc. India ink solution.
"The serum from rabbits, ,2 cc. per kilogram of body
weight, into which 5, cc, of India ink solution per
Kilogram of body weight " had been `injected 6 times
with 12 hours intervals was given 24 hours before
sensitization.
Discussion
Moldvan, Slovoaca of Zolog, Prof. Yun claimed
the existance of inhibitory substance against allergic
changes in the serum of the R.E,S. blockade. As ohs
erved in these experiment, the ´injection of serum from
rabbits blockaded with India ink solution, especially in
the group receiving the serum from single iniection of
India ink solution inhibited markedly allergic changes
in thymus. It is quite apparent that the serum of the
R. E. S. blockaded rabbits contain an inhibited subst-
ante against allergic changes.
Allergic changes in thymus were slightly inhibited.
in rabbits directly blockaded with India ink solution.
Jungeblut and Berlot, Gay and. Clark, Siegmond and
Okazaki previously descrived the inhibition of allergic
changes in the R.E.S. blockade. That is the inhibitory
substance against allergic´ changes were secreted from
the R. E. S..
Conclusions.
Studies on the relation between allergic changes in
thymus and the R. E. S. are reported.
1) The injection of serum from the R.E.S. blockade with
India ink solution inhibited allergic changes in
thymus.
2) Direct blockade of the R. E. S. slightly, inhibited,
allergic changes in thymus.
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